Quercetin Inhibits Colorectal Cancer Cells Induced-Angiogenesis in Both Colorectal Cancer Cell and Endothelial Cell through Downregulation of VEGF-A/VEGFR2

Colorectal cancer (CRC) aggressiveness is caused by angiogenesis which promotes the growth and metastasis associated with poor prognosis survival. The vascular endothelial factor-A (VEGF-A) its receptor (VEGFR-2) form major signaling pathway in angiogenesis. This study aimed to investigate anti-angiogenesis activity of quercetin both colorectal cells cells. tube formation human vein (HUVECs) was determined using conditioned media HT-29 treated co-cultured HUVECs. VEGF-A NF-?B p65 protein expressions quercetin-treated were fluorescence assay Western blot analysis. VEGFR-2 expression HUVECs after they Quercetin markedly decreased cell-induced also inhibited quercetin. Moreover, significantly translocation high dose Taken together, had an effect on inhibition related reduced